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| 等 级：长老 |
| 经 验 值：434 |
| 魅 力 值：466 |
| 龙 币：1380 |
| 积 分：820.6 |
| 注册日期：2004-06-22 |
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具体要求：
Qualifications:
PhD in Molecular Biology or Chemistry in last 3 years; - Master degree in Computer Science or Molecular Modeling; - Some experience in Bioinformatics.
International applicants are acceptable.
Positions: Postdoctoral position.
Project description:
Transcription factor Nrf2 regulates a battery of genes encoding carcinogen-detoxifying enzymes. The Keap1/Nrf2 complex is vital in regulating free Nrf2 available for activation of detoxifying enzymes. Small molecules that selectively modulate the Keap1/Nrf2 interaction would be of great value in dissecting the functional aspect of Keap1/Nrf2 interaction in cells. The selectivity of small molecule is essential. The first specific aim of this project is to develop a novel structure-based molecular modeling methodology to design selective chemical modulators of Keap1/nNrf2 interaction. Next objective is to extend the methodology for the general application in selectively modulating specific protein-protein interactions by chemical approach. Although the applicant is expected to involve in biochemical assays, he/she will spend most of the time on theoretical studies. This postdoctoral fellow will be under supervision of Dr. JH Wu..
Position Available Immediately
Contact Information:
Lady Davis Institute, Room 13 3755 Cote-Ste-Catherine, Rd. Montreal, Quebec H3T 1E2 Canada
Fax: (514)340-7502
E-mail:
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2004-11-02 14:13:36
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